Research progress in tofacitinib for juvenile idiopathic arthritis

doi:10.19803/j.1672-8629.20220611

Abstract

Abstract: Juvenile idiopathic arthritis, an autoimmune disease, is a common childhood arthritis with unclear etiology and high heterogeneity. Tofacitinib, as a novel oral specific inhibitor of small molecule Janus kinases (mainly JAK1 and JAK3), has revolutionized the treatment of several types of skin diseases in different age groups. Tofacitinib was approved in September 2020 for active polyarticular juvenile idiopathic arthritis 2 years of age and older by the United States Food and Drug Administration. There are relatively few applications in children with juvenile idiopathic arthritis, leaving evidence about safety, efficacy, and tolerability for use in children limited. This article summarizes the research progress in the treatment of juvenile idiopathic arthritis with tofacitinib in terms of the mechanism of action, pharmacokinetic characteristics, clinical application and safety so as to provide reference for future multicenter clinical studies.

Key words: tofacitinib, juvenile idiopathic arthritis, mechanism of action, pharmacokinetic profile, clinical applications, safety

CLC Number:

R971
R994

LI Yamei, SHUI Rong. Research progress in tofacitinib for juvenile idiopathic arthritis[J]. Chinese Journal of Pharmacovigilance, 2023, 20(8): 956-960.

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