The Mechanism of Toxicity Reaction Induced by Protamine Sulfate Injection

doi:10.19803/j.1672-8629.2021.12.13

Abstract

Abstract: Objective To analyze the pathogenesis of and risk factors for toxic reactions induced by protamine sulfate injection so as to provide reference for clinical safe use.Methods The clinical classification and pathogenesis of toxic reactions induced by protamine sulfate injection were analyzed, while a wide range of risk factors leading to toxic reactions was discussed. Results Risk factors for toxic reactions in clinic included the speed of administration, routes of administration, insufficient knowledge, and special populations.Conclusion It is recommended that effective control measures be taken, including the monitoring of medication, selection of a proper speed and route of administration, use of ultrafiltration, control over special populations, and effective information intervention.

Key words: protamine sulfate, injection, toxic reaction, pathogenesis, risk management

CLC Number:

R994.11

FAN Yan, WANG Dan, WANG Chunting. The Mechanism of Toxicity Reaction Induced by Protamine Sulfate Injection[J]. Chinese Journal of Pharmacovigilance, 2021, 18(12): 1159-1161.

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