氟替美维吸入粉雾剂致过敏性休克1例分析

doi:10.19803/j.1672-8629.20220298

中国药物警戒 ›› 2023, Vol. 20 ›› Issue (7): 829-832.
DOI: 10.19803/j.1672-8629.20220298

氟替美维吸入粉雾剂致过敏性休克1例分析

连玉菲, 邱学佳, 方灵芝, 张玥, 刘洪涛, 董占军^*

河北省人民医院药学部,河北石家庄 050051

收稿日期:2022-06-02 出版日期:2023-07-15 发布日期:2023-07-14
通讯作者: ^*董占军,男,硕士,主任药师,医院药学。
作者简介:连玉菲,女,硕士,副主任药师,临床药学。
基金资助:
河北省医学科学研究重点课题计划（20220811）

One case of anaphylactic shock induced by fluticasone furoate

LIAN Yufei, QIU Xuejia, FANG Lingzhi, ZHANG Yue, LIU Hongtao, DONG Zhanjun^*

Department of Pharmacy, Hebei Provincial People’s Hospital, Shijiazhuang Hebei 050051, China

Received:2022-06-02 Online:2023-07-15 Published:2023-07-14

摘要/Abstract

摘要： 目的探讨氟替美维吸入粉雾剂致过敏性休克发生的特点,为临床安全合理用药提供参考。方法分析某院1例使用氟替美维吸入粉雾剂导致过敏性休克的案例,结合诺氏不良反应评分,评价本次过敏性休克与怀疑药物的相关性。并通过文献回顾氟替美维吸入粉雾剂导致过敏性休克的原因及机制。结果根据患者的病史,氟替美维诺氏不良反应相关性评分得5分（可能相关）,考虑氟替美维致过敏性休克可能性大。患者发生过敏性休克可能主要由氟替美维吸入粉雾剂中辅料乳蛋白所致,但不完全排除主成分乌美溴铵相关。患者经对症治疗后好转。结论应常规询问过敏史,避免使用含有乳蛋白的吸入粉雾剂或其他药物,以免引起严重过敏反应。

关键词: 氟替美维, 乌美溴胺, 吸入粉雾剂, 过敏性休克, 乳糖蛋白

Abstract: Objective To investigate the characteristics of anaphylactic shock induced by fluticasone furoate in order to provide reference for clinical safe and rational drug use. Methods One case of anaphylactic shock caused by the use of fluticasone furoate and treated in our hospital was analyzed. The correlations between anaphylactic shock and the suspected drug were studied using the Knoop’s adverse reaction score. The causes and mechanisms of anaphylactic shock caused by fluticasone furoate were studied by reviewing literature. Results According to the patient’s medical history, the correlation score of adverse reactions of fluticasone furoate was 5 points (possibly related). It was likely that allergic shock was caused by fluticasone furoate, or rather, by the adjuvant milk protein contained, but it was also possible that the main ingredient - umeclidinium bromide-was also involved. Conclusion Patients with a history of milk protein allergy should be routinely inquired about their allergy history, and the use of inhaled powder or other drugs containing milk protein as excipients should be avoided so as to prevent serious allergic reactions.

Key words: fluticasone furoate, adjuvant, powder for inhalation, anaphylactic shock, lactose protein

中图分类号:

连玉菲, 邱学佳, 方灵芝, 张玥, 刘洪涛, 董占军. 氟替美维吸入粉雾剂致过敏性休克1例分析[J]. 中国药物警戒, 2023, 20(7): 829-832.

LIAN Yufei, QIU Xuejia, FANG Lingzhi, ZHANG Yue, LIU Hongtao, DONG Zhanjun. One case of anaphylactic shock induced by fluticasone furoate[J]. Chinese Journal of Pharmacovigilance, 2023, 20(7): 829-832.

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氟替美维吸入粉雾剂致过敏性休克1例分析

One case of anaphylactic shock induced by fluticasone furoate

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