中国药物警戒 ›› 2022, Vol. 19 ›› Issue (4): 460-464.
DOI: 10.19803/j.1672-8629.2022.04.26

• 综述 • 上一篇    

中药治疗免疫性血小板减少症的临床和实验研究进展

罗雅琴1, 黄伟2,3,*   

  1. 1山东中医药大学附属医院,山东 济南 250014;
    2山东省中医药研究院,山东 济南 250014;
    3齐鲁工业大学(山东省科学院),山东省分析测试中心,济南 250014;
  • 收稿日期:2020-11-26 出版日期:2022-04-15 发布日期:2022-04-15
  • 通讯作者: *黄伟,男,博士,助理研究员,中药药效物质基础及作用机理。E-mail：huangwei986@126.com
  • 作者简介:罗雅琴,女,硕士,主治医师,中西医结合治疗血液病的临床与实验。
  • 基金资助:
    国家自然科学基金（81704029）; 齐鲁卫生与健康杰出青年人才资助项目（鲁卫人才字〔2020〕 3号）; 中央本级重大增减支项目“名贵中药资源可持续利用能力建设项目”(2060302); 全国名老中医药专家刘持年传承工作室建设项目（国中医药人教发〔2014〕20号）; 山东省中医药科技面上项目（2020M027）

Advances in clinical and experimental research on treatments of immune thrombocytopenia with traditional Chinese medicine

LUO Yaqin1, HUANG Wei2,3,*   

  1. 1The Affiliated Hospital of Shandong University of Chinese Medicine, Jinan Shandong 250014, China;
    2Shandong Academy of Chinese Medicine, Jinan Shandong 250014, China;
    3Qilu University of Technology/Shandong Academy of Sciences/Shandong Analysis and Test Center, Jinan Shandong 250014, China
  • Received:2020-11-26 Online:2022-04-15 Published:2022-04-15

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摘要： 免疫性血小板减少症（immune thrombocytopenia, ITP）是临床上常见的出血性疾病,以外周血血小板数目减少为特征。轻者无明显出血症状,严重者可出现皮肤黏膜出血、月经过多,甚至内脏及颅内出血,危及生命。ITP发病机制目前尚不明确,可能主要与自身免疫有关。ITP尚无法根治,西医以糖皮质激素为首选治疗药物,但随着激素的撤减,许多患者出现激素依赖、易复发、治疗效果差的情况,严重增加患者负担。近年来,临床上应用中医或中西医结合治疗ITP取得较大进展,且具有副作用小、作用持久、治疗费用低廉等优势。本文主要从中医理论、临床和实验研究方面,归纳总结了近5年来中药治疗ITP的研究进展,以期为中医药防治ITP作用机制的深入研究提供参考,并为中医药在临床上更好地防治该疾病提供理论依据。

关键词: 免疫性血小板减少症, 中医药, 药品不良反应

Abstract: Immune thrombocytopenia (ITP) is a common clinical bleeding disorder characterized by a decrease in the number of peripheral blood platelets. Mild cases have no obvious bleeding symptoms. In severe cases, skin and mucous membrane bleeding, menorrhagia, and even internal organ bleeding and intracranial bleeding may occur, which is life-threatening. The pathogenesis of ITP is currently unclear, and it is believed to be related to autoimmunity. ITP has never been cured once for all. Western medicine uses glucocorticoids as the first choice for treatment. However, with the withdrawal of hormones, many patients become hormone-dependent and prone to relapse, along with poor long-lasting effects and high costs. In recent years, clinical applications of traditional Chinese medicine or integrated traditional Chinese and western medicine have made great progress in the treatment of ITP. This paper summarizes the advances in the treatment of ITP with TCM in the past five years from theoretical, clinical and experimental perspectives, hoping to provide reference for the in-depth study of the mechanism by which Chinese medicine helps prevent and treat ITP so as to contribute to the prevention and treatment of the disease.

Key words: immune thrombocytopenia, traditional Chinese medicine, adverse drug reaction

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