58例氟比洛芬不良反应文献分析

doi:10.19803/j.1672-8629.2022.04.20

中国药物警戒 ›› 2022, Vol. 19 ›› Issue (4): 436-440.
DOI: 10.19803/j.1672-8629.2022.04.20

58例氟比洛芬不良反应文献分析

黄丽¹, 魏龙¹, 李何美¹, 易丹^2,*

¹株洲市中心医院药学部,湖南株洲 412000;
²株洲市中心医院药物临床试验中心,湖南株洲 412000

收稿日期:2020-06-10 出版日期:2022-04-15 发布日期:2022-04-15
通讯作者: ^*易丹,女,硕士,副主任药师,临床药学。E-mail：12213458@qq.com
作者简介:黄丽,女,硕士,副主任药师,医院药学。
基金资助:
株洲市科学技术局2019年度科技指导性项目

Literature review of 58 cases of adverse drug reactions induced by flurbiprofen

HUANG Li¹, WEI Long¹, LI Hemei¹, YI Dan^2,*

¹Department of Pharmacy, Zhuzhou Central Hospital, Zhuzhou Hunan 412000, China;
²Drug Clinical Trial Center, Zhuzhou Central Hospital, Zhuzhou Hunan 412000, China

Received:2020-06-10 Online:2022-04-15 Published:2022-04-15

摘要/Abstract

摘要： 目的分析氟比洛芬不良反应发生特点,为临床安全用药提供参考。方法以“氟比洛芬”“不良反应”“病例”为检索词,检索中国知网、万方数据、维普网;以“flurbiprofen”“adverse reaction”“case reports”为检索词检索PubMed,检索时间从建库至2019年12月31日。纳入有效文献45篇,提取病例58例,并进行统计分析。结果不良反应累及系统-器官以皮肤及其附件损害、中枢神经系统损害为主;不良反应多发生在用药1 h内;静脉推注不良反应发生率最高。结论临床应高度重视氟比洛芬不良反应的发生,加强用药监护和防范。

关键词: 氟比洛芬, 药品不良反应, 文献分析

Abstract: Objective To analyze the characteristics of adverse reactions induced by flurbiprofen and provide reference for safe medication. Methods Using "flurbiprofen" "adverse reaction" "case" as key words, the related articles in the CNKI, Wanfang Database, VIP and Pubmed from established to December 31, 2019 were searched for and retrieved. Results The adverse reactions were mostly skin and accessory damage, and damage to the central nervous system, which occurred within one hour of medication. The highest incidence of adverse reactions was due to intravenous injection. Conclusion It is important for clinicians to be alert to the adverse reactions of flurbiprofen, enhance the monitoring and guidance of drug use, and ensure the safety of medication.

Key words: flurbiprofen, adverse drug reaction, literature review

中图分类号:

R994.11

黄丽, 魏龙, 李何美, 易丹. 58例氟比洛芬不良反应文献分析[J]. 中国药物警戒, 2022, 19(4): 436-440.

HUANG Li, WEI Long, LI Hemei, YI Dan. Literature review of 58 cases of adverse drug reactions induced by flurbiprofen[J]. Chinese Journal of Pharmacovigilance, 2022, 19(4): 436-440.

参考文献

[1] BOSSO JV, CREIGHTCM D, STEVENSON DD.Flurbiprofen (Ansaid) Cross-sensitivity in an Aspirin-sensitive Asthmatic Patient[J]. Chest, 1992, 101(3): 856-858.
[2] MATTIA G, LUCREZIA S, SIMONA B, et al.Anaphylaxis to over-the-counter flurbiprofen in a child[J]. Pharmacology, 2017, 99(3-4): 121-123.
[3] MEHRA KK, RUPAWALA AH, GOGTAY NJ, et al.Immediate hypersensitivity reaction to a single oral dose of flurbiprofen[J]. J Postgrad Med, 2010, 56(1): 36-7.
[4] GIUSEPPE F, CLAUDIO DS, GIOVANNI M, et al.Cross-reaction allergic pancreatitis with ketoprofen and flurbiprofen[J]. Pancreas, 2007, 35(2): 187-188.
[5] Anesthesiology of Jiangxi. The 14 th Annual Conference of Anesthe-siology in Jiangxi[C]. Jiangxi: [Publisher unknown], 2013.
[6] HEALY CM, HORNHILL MH.An association between recurrent oro-genital ulceration and non-steroidal anti-inflammatory drugs[J]. J Oral Pathol Med, 1995, 24(1): 46-48.
[7] LIU XL, JIANG JC.Prevention and nursing of convulsions caused by flurbiprofen axetil[J]. Chinese Journal of Aesthetic Medicine(中国美容医学),2011, 20(3): 347.
[8] KANG X, JI CY, HAN YM, et al.A case of convulsion and anaphylactic shock caused by flurbiprofen axetil[J]. Chin J Gen Pract(中国全科医学杂志), 2011, 10(1): 57.
[9] XU YR, XU KZ.5 cases of epileptiform seizures caused by flurbiprofen axetil[J]. Chongqing Medicine(重庆医学), 2010, 39(20): 2844-2845.
[10] BANAL F, LECOULES S.Acute renal insufficiency after flurbiprofen treatment in a patient treated with angiotensin convertingenzyme inhibitor[J]. La Revue de médecine interne, 2008, 29(7): 593-595.
[11] NOBORU T, NOBUHIKO I, JIRO I, et al.A case of acute interstitial nephritis induced by flurbiprofen[J]. Jpn J Med, 1987, 26(2): 230-233.
[12] WU XM, LI Y, YANG LJ.Analysis of 7 cases of allergic reaction caused by flurbiprofen axetil in anesthetized patients[J]. China Pharmacist(中国药师), 2011, 14(10): 1510-1511.
[13] DOMENICO S, GIUSEPPE V, STEFANIA R, et al.Drug-induced TINU syndrome and genetic characterization[J]. Clin Nephrol, 2012, 78(3): 230-6.
[14] ZOU XJ, TONG HL, YANG P.A case of severe bronchospasm induced by flurbiprofen axetil[J]. J Clin Anesthesiol(临床麻醉学杂志), 2016, 32(6): 585.
[15] CALAPAI G, IMBESI S, CAFEo V, et al.Fatal hypersensitivity reaction to an oral spray of flurbiprofen: a case report[J]. Journal of Clinical Pharmacy and Therapeutics, 2013, 38(4): 337-338.
[16] BALTA1 I, SIMSEK H, SIMSEK GG, et al. Flurbiprofen-induced generalized bullous fixed drug eruption[J]. Hum Exp Toxicol, 2014, 33(1): 106-108.
[17] NICOLA DM, GIUSEPPE S, PASQUALE P, et al.Acute localized exanthematous pustulosis caused by flurbiprofen[J]. Cutis, 2016, 98(5): E9-E11.
[18] ROMANO A, PIETRANTONIO F.Delayed hypersensitivity to furbiprofen[J]. Journal of Internal Medicine, 1997, 241(1): 81-83.
[19] ZENG QL, HUANG JW, HUANG SA.A case of dyspnea caused by flurbiprofen axetil[J]. Evaluation and Analysis of Drug-use in Hospitals of China(中国医院用药评价与分析), 2018, 18(10): 1440.
[20] WU TG.Analysis of a case of convulsion caused by flurbiprofen axetil[J]. Chin J Misdiagn(中国误诊学杂志), 2007, 7(19): 4678-4679.
[21] ENEVOLDSON TP, WILES CM.Acute parkinsonism associated with flurbibrofen[J]. BMJ, 1990, 300(6723): 540-541.
[22] ZHENG ZQ, LUO JY, WU ZJ, et al.A case of flurbiprofen axetil-induced asthma and supraventricular tachycardia[J]. Chinese Journal of Clinical Pharmacy(中国临床药学杂志), 2019, 28(1): 70-71.
[23] WEN CS, LING P.Flurbiprofen axetil, nasal polyps, and status asthmaticus: an unusual case report[J]. Journal of Asthma, 2011, 48(6): 647-649.
[24] SERKAN D, MEHMET C, KUTAY D, et al.Prolonged cholestatic jaundice associated with flurbiprofen[J]. Journal of Pharmacy Practice, 2014, 27(4): 396-398.
[25] LIU H, GUO DH, SONG YD, et al.Review on cases and literature of flurbiprofen (axetil)-induced liver damage[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2018,15(5): 291-295.
[26] JEFFREY K, MICHAEL W, KEVIN M, et al.Flurbiprofen-associated acute tubulointerstitial nephritis[J]. Am J Nephrol, 1991, 11(2): 144-146.
[27] QI F, ZHANG T, WU LL.A case of adverse reaction caused by compound ossotide injection and flurbiprofen axetil[J]. China Pharmacist(中国药师), 2014, 17(7): 1202-1203.
[28] MUGE G, BASAK UK, AA, et al. Flurbiprofen-associated hemolytic anemia[J]. American Journal of Therapeutics, 2019, 26(6): e723-e726.
[29] WANG WG, GUO WS.Meta analysis of the effect of flurbiprofen axetil on blood coagulation function after analgesia[J]. Chin J Orthop Trauma(中华创伤骨科杂志), 2018, 20(10): 889-896.
[30] SUN LR, ZHANG HM, GUO QS, et al.Laryngeal edema induced by flurbiprofen axetil[J]. ADRJ(药物不良反应杂志), 2019, 21(4): 290-291.

58例氟比洛芬不良反应文献分析

Literature review of 58 cases of adverse drug reactions induced by flurbiprofen

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