木犀草素抗脑缺血的网络药理学研究

doi:10.19803/j.1672-8629.2021.08.12

中国药物警戒 ›› 2021, Vol. 18 ›› Issue (8): 760-762.
DOI: 10.19803/j.1672-8629.2021.08.12

木犀草素抗脑缺血的网络药理学研究

孙倩¹, 陈红², 郭欣欣¹, 刘胜伟³, 廖原⁴, 贾玲玲^1,*

¹德州市人民医院,山东德州 253000;
²德州市第七人民医院,山东德州 253000;
³重庆医科大学附属永川医院药学部,重庆 402160;
⁴杭州师范大学生命与环境科学学院,浙江杭州 310036

收稿日期:2020-07-06 出版日期:2021-08-15 发布日期:2021-08-17
通讯作者: ^*贾玲玲,女,本科,主管药师,医院药学与药理学。E-mail：doumaoji@163.com
作者简介:孙倩,女,本科,主管药师,医院药学与药物分析。
基金资助:
国家自然科学基金青年科学基金项目（31701189）; 重庆市永川区科委课题（Ycstc2017nc5003）

Network Pharmacology of Luteolin Protecting against Cerebral Ischemia

SUN Qian¹, CHEN Hong², GUO Xinxin¹, LIU Shengwei³, LIAO Yuan⁴, JIA Lingling^1,*

¹Dezhou People's Hospital, Dezhou Shandong 253000, China;
²Dezhou Seventh People's Hospital, Dezhou Shandong 253000, China;
³Department of Pharmacy, Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China;
⁴College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou Zhejiang 310036, China

Received:2020-07-06 Online:2021-08-15 Published:2021-08-17

摘要/Abstract

摘要： 目的通过网络药理学方法研究木犀草素抗脑缺血（cerebral ischemia, CI）的生物机制。方法通过网络药理学分析平台数据库（TCMSP）筛选木犀草素的作用靶标;通过GeneCards数据库筛选CI疾病的靶基因。采用cytoscape软件构建木犀草素-靶点网络图,利用STRING数据库进行蛋白互作网络分析,并对相关靶点进行基因本体（GO）富集分析和京都基因与基因组百科全书（KEGG）信号通路分析。结果筛选后获得木犀草素作用于CI的靶点有50个,关键靶点通过调控血管增殖与生成、炎症反应、凋亡过程等功能发挥抗CI的作用。结论木犀草素作用于脑缺血主要是通过调节氧化应激反应、血管平滑肌增殖及再生、凋亡信号通路等生物过程,以及PI3K-Akt信号通路和IL-17信号通路等发挥作用。

关键词: 木犀草素, 脑缺血, 网络药理学, 蛋白相互作用, 富集分析

Abstract: Objective To study the biological mechanism of luteolin protecting against cerebral ischemia by network pharmacology. Methods The target of luteolin was screened by TCMSP database, target genes of CI diseases were screened by Gene Cards database, Luteolin-target network was constructed by Cytoscape software, protein-protein interaction(PPI) network was analyzed using STRING database, GO enrichment analysis and KEGG signal pathway analysis were performed on the relevant targets. Results 50 targets of luteolin on CI was acquired, and key targets protecting against CI by regulating vascular proliferation and generation, inflammatory response, apoptosis and other functions. Conclusion Luteolin plays an important role in cerebral ischemia by regulating oxidative stress, proliferation and regeneration of vascular smooth muscle, apoptotic signaling pathway, PI3K Akt signaling pathway and IL-17 signaling pathway

Key words: luteolin, cerebral ischemia, network pharmacology, protein-protein interaction, enrichment analysis

中图分类号:

R285 R966

孙倩, 陈红, 郭欣欣, 刘胜伟, 廖原, 贾玲玲. 木犀草素抗脑缺血的网络药理学研究[J]. 中国药物警戒, 2021, 18(8): 760-762.

SUN Qian, CHEN Hong, GUO Xinxin, LIU Shengwei, LIAO Yuan, JIA Lingling. Network Pharmacology of Luteolin Protecting against Cerebral Ischemia[J]. Chinese Journal of Pharmacovigilance, 2021, 18(8): 760-762.

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木犀草素抗脑缺血的网络药理学研究

Network Pharmacology of Luteolin Protecting against Cerebral Ischemia

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