中国药物警戒 ›› 2011, Vol. 8 ›› Issue (12): 759-762.

• 药品不良反应监测 • 上一篇    下一篇

189例穿琥宁注射剂不良反应文献分析

曾聪彦, 丘凯悦   

  1. 广州中医药大学附属中山医院,广东 中山 528400
  • 收稿日期:2011-05-29 出版日期:2011-12-10 发布日期:2015-07-30
  • 作者简介:曾聪彦,男,主任中药师,硕士生导师,医院药学工作。
  • 基金资助:
    广东省中山市科技计划资助项目（20091A028）

Literature Analysis on 189 Cases Adverse Reaction of Chuanhuning Injection

ZENG Cong-yan, QIU Kai-yue   

  1. Zhongshan Hospital, Guangzhou University of TCM, Guangdong Zhongshan 528400, China
  • Received:2011-05-29 Online:2011-12-10 Published:2015-07-30

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摘要： 目的 探讨穿琥宁注射剂所致不良反应的一般规律及特点,指导临床合理用药。方法 通过检索1998~2010年国内公开发表的医学期刊报道应用穿琥宁注射剂致不良反应案例,并利用文献计量学方法进行分析。结果 穿琥宁注射剂所致的189例不良反应与性别无关,多发生于<10岁年龄组,其出现时间多发生于用药后的前30分钟内,不良反应临床表现复杂多样,累及机体多个系统-器官损伤,主要以过敏反应和血小板减少症为主,经对症治疗,预后多良好。结论 临床医师、药师应了解穿琥宁注射剂所致不良反应的规律和特点,加强其用药监测,以减少不良反应的发生。

关键词: 穿琥宁注射剂, 药品不良反应, 文献, 分析

Abstract: Objective To explore the general pattern and characteristics of adverse drug reactions(ADR) induced by Chuanhuning injection so as to provide references for clinical rational drug use. Methods ADR cases induced by Chuanhuning injection that retrieved from domestic medical journals during 1998~2010 were analyzed statistically. Results ADR of Chuanhuning injection were independent of patient's sex, and mostly occurred in the <10 group. They usually occurred in the first 30 minutes after taking the drug. ADR could involve in multiple organs and systems, and clinical manifestations were various, mainly were allergic reaction and thrombocytopenia,symptomatic treatment,prognosis much good. Conclusion Doctors and pharmacists should know the pattern and characteristics of ADR, and the use of Chuanhuning injection should be under strict monitoring to reduce the occurrence of serious ADR.

Key words: Chuanhuning injection, adverse drug reaction, literature, analysis

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