栀子的药效与毒性及其作用机制研究进展

doi:10.19803/j.1672-8629.2021.01.20

中国药物警戒 ›› 2021, Vol. 18 ›› Issue (1): 94-99.
DOI: 10.19803/j.1672-8629.2021.01.20

栀子的药效与毒性及其作用机制研究进展

王晓慧^1,2, 张帆¹, 席莉莉¹, 夏文彬^1,2, 魏玉辉^1,*

¹兰州大学第一医院药剂科;
²兰州大学药学院, 甘肃兰州 730020

收稿日期:2020-06-03 修回日期:2021-01-18 出版日期:2021-01-15 发布日期:2021-01-18
通讯作者: ^*魏玉辉,男,博士,副教授·硕导,医院药学与药事管理。E-mail:yhwei@lzu.edu.cn
作者简介:王晓慧,女,硕士,药学,中药药效及毒理学。
基金资助:
国家自然科学基金委面上项目(81960646):基于CAR+FXR双靶点筛选具有“利胆退黄”双重功效的天然活性化合物; 国家自然科学基金应急管理项目(81641142):基于肝肾转运体和代谢酶介导胆酸盐阐释栀子“引湿热自小便而出”的中医内涵; 国家自然科学基金青年科学基金项目(81702853):Asbt(Slc10a2)抑制效应在栀子调控的回肠-粪便利胆途径中的作用研究

Research Progress on Pharmacological Effects and Toxicity of Gardenia jasminoides Ellis and Related Mechanisms

WANG Xiaohui^1,2, ZHANG Fan¹, XI Lili¹, XIA Wenbin^1,2, WEI Yuhui^1,*

¹The First Hospital of Lanzhou University,Lanzhou Gansu 730000,China;
²School of Pharmacy,Lanzhou University,Lanzhou Gansu 730020,China

Received:2020-06-03 Revised:2021-01-18 Online:2021-01-15 Published:2021-01-18

摘要/Abstract

摘要： 栀子是临床广泛应用的药食两用性中药,主要用于治疗急/慢性病毒性肝炎、高胆红素血症、少儿发热、高脂血症、糖尿病等。近年来,有关栀子毒性及其造成不良后果的报道和研究越来越多,限制了栀子的临床使用。为充分发挥栀子的药效并避免或减轻栀子引起的毒性,本文综述了栀子的药效和毒性及其作用机制,旨在为临床上栀子的合理使用提供参考。

关键词: 栀子, 药效, 肝毒性, 肾毒性

Abstract: Gardenia jasminoides Ellis (G.jasminoides)is a commonly used traditional Chinese medicine and also a healthy food in China.It is mainly used for the treatment of acute/chronic viral hepatitis,hyperbilirubinemia,children's fever,hyperlipidemia and diabetes,with significant pharmacological effects.However,in recent years,more reports and studies have suggested that G.jasminoides has apparent toxicity and results in adverse effects,which restricts clinical administration of G.jasminoides.Therefore,in order to improve the rational use of G.jasminoides in clinic,enhance the efficacy of G.jasminoides and prevent or reduce the toxicity caused by gardenia,this review summarized the pharmacological effects and toxicity of G.jasminoides and the relatedt mechanisms.

Key words: Gardenia jasminoides Ellis, pharmacodynamic effect, hepatotoxicity, nephrotoxicity

中图分类号:

R285

王晓慧, 张帆, 席莉莉, 夏文彬, 魏玉辉. 栀子的药效与毒性及其作用机制研究进展[J]. 中国药物警戒, 2021, 18(1): 94-99.

WANG Xiaohui, ZHANG Fan, XI Lili, XIA Wenbin, WEI Yuhui. Research Progress on Pharmacological Effects and Toxicity of Gardenia jasminoides Ellis and Related Mechanisms[J]. Chinese Journal of Pharmacovigilance, 2021, 18(1): 94-99.

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栀子的药效与毒性及其作用机制研究进展

Research Progress on Pharmacological Effects and Toxicity of Gardenia jasminoides Ellis and Related Mechanisms

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