中国药物警戒 ›› 2020, Vol. 17 ›› Issue (8): 449-454.
DOI: 10.19803/j.1672-8629.2020.08.01

• 基础与临床研究 • 上一篇    下一篇

清热散结胶囊对细菌性呼吸道感染模型的作用研究

孙静1, 高英杰1, 郭姗姗1, 赵荣华1, 宋太发2, 李林梅2, 姚荣妹1, 崔晓兰1, 李晓璐3, 时宇静1,*   

  1. 1中国中医科学院中药研究所,北京100700;
    2湖南天济草堂制药股份有限公司,湖南 长沙 410205;
    3卫生部北京医院心内科,北京 100730
  • 收稿日期:2020-07-31 修回日期:2020-07-31 出版日期:2020-08-15 发布日期:2020-07-31
  • 通讯作者: *时宇静,女,博士,副研究员,中药抗病毒及抗感染药理。E-mail: yjshi@icmm.ac.cn
  • 作者简介:孙静,女,博士,中药药理。

Effect of Qingre Sanjie Capsules on Model of Bacterial Respiratory Tract Infections

SUN Jing1, GAO Yingjie1, GUO Shanshan1, ZHAO Ronghua1, SONG Taifa2, LI Linmei2, YAO Rongmei1, CUI Xiaolan1, LI Xiaolu3, SHI Yujing1,*   

  1. 1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;
    2Hunan Tianji Caotang Pharmaceutical Co., Ltd, Changsha Hunan 410205, China;
    3Department of Cardiology, Beijing Hospital, Beijing 100730, China
  • Received:2020-07-31 Revised:2020-07-31 Online:2020-08-15 Published:2020-07-31
  • Supported by:
    国家自然科学基金项目（81773977）：与流感病毒NP蛋白发生相互作用的宿主蛋白靶点辨识及栀子环烯醚萜苷的干预作用研究

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摘要： 目的 明确清热散结胶囊对细菌性呼吸道感染动物模型的作用,为临床应用提供基础。方法 实验动物按体质量随机分为7组,分别为正常对照组、模型对照组、阿莫西林胶囊对照组、穿心莲内酯滴丸对照组,清热散结胶囊分为3个剂量组（高、中、低剂量组）。采用金黄色葡萄球菌、乙型溶血性链球菌、肺炎链球菌感染致小鼠肺炎模型,乙型溶血性链球菌感染致大鼠急性咽炎模型,通过检测肺指数、小鼠死亡率、平均生存天数、大鼠咽部病变等指标评价清热散结胶囊对细菌性呼吸道感染的作用。结果 清热散结胶囊3个剂量组可显著降低乙型溶血性链球菌感染致小鼠死亡率,延长小鼠平均存活天数,减轻大鼠咽喉部炎症病变,并降低肺炎链球菌感染小鼠肺指数。结论 清热散结胶囊具有良好的体内抗菌作用,且对乙型溶血性链球菌感染致大鼠急性咽炎模型具有显著治疗作用。

关键词: 细菌性呼吸道感染, 急性咽炎, 清热散结胶囊, 乙型溶血性链球菌

Abstract: Objective To study the effect of Qingre Sanjie capsules on the animal model of bacterial respiratory tract infections in order to provide reference for clinical application. Methods Laboratory animals were randomly divided into 7 groups according to body weight: normal group, model group, amoxicillin capsule group, andrographolide dropping pill group and 3 different-dose groups of Qingre Sanjie capsules. Four animal models were established, including three models of pneumonia caused by staphylococcus aureus, beta hemolytic streptococcus and streptococcus pneumoniae infection in mice and one acute pharyngitis model induced by beta hemolytic streptococcus in rats. The lung index, lung index inhibition rate, mouse mortality, the average survival time, pharyngeal lesion scores of rats and pathological examination were used to evaluate the efficacy of Qingre Sanjie capsules against respiratory bacterial infections. Results Qingre Sanjie capsules at the three doses could significantly reduce the mortality, prolong the average survival time, alleviate the pharyngeal lesions of mice infected with beta-hemolytic streptococcus, and reduce the lung index of mice infected with streptococcus pneumonia. Conclusion All the three doses of Qingre Sanjie capsules could effectively alleviate the symptoms of acute pharyngitis caused by beta-hemolytic streptococcus. They also have significant antibacterial effect in vivo.

Key words: bacterial respiratory tract infection, acute pharyngitis, Qingre Sanjie capsule, beta-hemolytic streptococcus

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