中国药物警戒 ›› 2018, Vol. 15 ›› Issue (8): 449-451.

• 基础与临床研究 •    下一篇

金鸡毛草水提取物大鼠30天喂养毒性研究

乐暾, 牟华明*, 李晶, 舒朝林, 王蕾   

  1. 重庆三峡中心医院,重庆 万州 404000
  • 收稿日期:2018-10-11 修回日期:2018-10-11 出版日期:2018-08-20 发布日期:2018-10-11
  • 通讯作者: 牟华明,男,博士,主任医师,教授,心血管疾病临床诊疗。E-mail：mouhm2002@aliyun.com
  • 作者简介:乐暾,女,硕士,主治医师,消化内科疾病临床诊疗。
  • 基金资助:
    重庆市社会事业与民生保障科技创新专项(一般)（cstc2016shmszx130074）：一味降糖中药金鸡毛草院内制剂开发与应用; 重庆市卫计委中医药科技项目（ZY201703065）：金鸡毛草水提取物对糖尿病足大鼠炎症抑制作用的研究

Study on Toxicity of Gynura Divaricata Aqueous Extract by Gavage for 30 Days in Rats

YUE Tun, MOU Huaming*, LI Jing, SHU Chaolin, WANG Lei   

  1. Chongqing Three Gorges Central Hospital, Chongqing Wanzhou 404000, China
  • Received:2018-10-11 Revised:2018-10-11 Online:2018-08-20 Published:2018-10-11

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摘要： 目的 探讨金鸡毛草水提取物的安全性,为其应用提供毒理学安全依据。方法 80只大鼠,雌雄各半,随机分为4组,分别以蒸馏水以及相当于20、10、4 g·kg-1生药量的金鸡毛草水提取物,每天1次,灌胃30天。实验期间观察大鼠一般情况,每6天测大鼠体重,实验末期计算大鼠脏器指数,检测血液细胞学、血液生化学指标,并做大鼠脏器病理组织学检查。结果 金鸡毛草水提物各剂量组大鼠精神状态、行为活动、体重、血液细胞学指标、血液生化指标及脏器指数与对照组相比未见明显差异,心脏、肝脏、脾脏、胃、肾脏、睾丸等组织病理学检测未见明显与药物毒性相关的病理变化。结论 金鸡毛草水提物30天喂养实验对大鼠无明显毒性反应。

关键词: 金鸡毛草, 大鼠, 灌胃, 长期毒性

Abstract: Objective To investigate the safety of Gynura divaricata aqueous extract, and to provide toxicological basis for its application. Methods 80 rats were randomly divided into 4 groups, each group was given distilled water and Gynura divaricata aqueous extract intragastrically in dose of 20, 10, 4 g·kg-1 for 30 days. Parameters examined included general condition, body weight, organ coefficient, blood cell, blood biochemistry, and histopathological examination. Results The mental state, behavioral activities, weights, blood cell, blood biochemistry, organ coefficient in rats had no significant difference by comparing with control group. The histopathological examination of heart, liver, spleen, stomach, kidney, testis, ect did not discover singificant pathological changes related to drug toxicity. Conclusion The 30 days feeding test of Gynura divaricata aqueous extract has no siginficant toxicity to rats.

Key words: Gynura divaricata aqueous extract, rats, gavage, chronic toxicity

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