中国药物警戒 ›› 2013, Vol. 10 ›› Issue (3): 178-180.

• 医院药事管理与合理用药 • 上一篇    下一篇

门急诊“超说明书”用药处方点评分析

刘辽,蒋丹,贾萍*,徐文芳   

  1. 四川省妇女儿童医院药剂科,四川成都 610031
  • 收稿日期:2012-12-06 修回日期:2016-03-09 出版日期:2013-03-08 发布日期:2016-03-09
  • 通讯作者: 贾萍,女,主任药师,医院药学。E-mail：jp178@tom.com
  • 作者简介:刘辽,男,主管药师,临床药学。

Analysis on Off-Label Use at Outpatient and Emergency Department

LIU Liao ,JIANG Dan ,JIA Ping* ,XU Wen -fang   

  1. Dept.of Pharmacy, Sichuan Provincial Hospital for Women and Children, Sichuan Chengdu 610031, China
  • Received:2012-12-06 Revised:2016-03-09 Online:2013-03-08 Published:2016-03-09

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摘要： 目的 了解我院门急诊超说明书情况并进行分析,为临床合理用药提供参考。方法 抽取我院2012 年6 月至2012 年11 月门急诊处方,根据药品说明书内容,对其中超说明书用药进行统计。结果抽取600 张处方,共发现超说明书用药处方63 张,主要包括超剂量（33.3%）、超适应证（23.8%)、超用药途径（20.6%）等。超说明书用药示例主要包括硝苯地平用于先兆流产、盐酸氨溴索注射液雾化用于呼吸道感染、麻杏甘石合剂治疗小儿呼吸道感染等。结论门急诊超说明书用药较为普遍,医疗过程中存在很大的风险,因此医院应重视超说明书用药,建立相应的管理制度与流程,保障患者的用药安全。

关键词: 超说明书用药, 调查分析

Abstract: Objective To analyze the situation of off-label use at outpatient and emergency department in our hospital for references of rational drug use in the clinic. Methods The prescriptions of outpatient and emergency department from June 2012 to Nov. 2012 were selected in our hospital. The off-label use was analyzed according to the package inserts. Results Of the total 600 prescriptions, 63 ones involved off -label use. The problems were mainly over dosage(33.3%), beyond indication(23.8%), route of medication(20.6%) etc. Examples of off-label use mainly included nifedipine for the treatment of preterm labor, ambroxol hydrochloride injection nebulized for the treatment of respiratory tract infections, maxingganshi decoction for the treatment of respiratory tract infections in children etc. Conclusion The off -label use is widespreaded at outpatient and emergency department. Risks exist during the health care process. It is sensible for our hospital to pay great attention on off-label use to establish corresponding control system and procedure, so as to ensure safe use of drug in patients.

Key words: off-label use, investigation and analysis

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