中国药物警戒 ›› 2020, Vol. 17 ›› Issue (5): 267-271.
DOI: 10.19803/j.1672-8629.2020.05.03

• 新型冠状病毒肺炎诊疗药品安全研究专栏 • 上一篇    下一篇

肾素-血管紧张素系统在COVID-19中作用及药物干预

李思铮1,2, 胡广1, 何敬成3, 胡宇驰4, 李志勇5, 靳洪涛1, 6*   

  1. 1 中国医学科学院药物研究所新药安全评价研究中心,北京 100050;
    2 南开大学药学院,天津 300350;
    3 南方医科大学顺德医院,广东 佛山 528000;
    4 北京市药品检验所,北京 102206;
    5 中央民族大学药学院,北京 100081;
    6 北京协和建昊医药技术开发有限责任公司,北京 100176
  • 收稿日期:2020-03-16 修回日期:2020-06-22 出版日期:2020-05-15 发布日期:2020-05-13
  • 通讯作者: *靳洪涛,男,博士,研究员·硕导,药物毒性机制与干预研究。E-mail：jinhongtao@imm.ac.cn
  • 作者简介:李思铮,男,本科,药物毒性机制与干预研究。
  • 基金资助:
    重大新药创制专项（2018ZX09201017-005,2018ZX09711001-002-001,2018ZX09711001-011）：吸入毒性和儿童用药等特色创新药物安全性评价关键技术研究; 新技术新方法在药物毒性中的应用,十三五重大专项定向委托项目-尘肺治疗药物和防治关键技术研究; 中国医学科学院医学与健康科技创新工程项目（2017-I2M-1-01）

The Role of Renin-angiotensin System in COVID-19 and Drug Intervention

LI Sizheng1,2, HU Guang1, HE Jingcheng3, HU Yuchi4, LI Zhiyong5, JIN Hongtao1, 6*   

  1. 1 New Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;
    2 College of Pharmacy, Nankai University, Tianjin 300350, China;
    3 Shunde Hospital of Southern Medical University, Foshan Guangdong 528000, China;
    4 Beijing Institute For Drug Control, Beijing 102206, China;
    5 School of Pharmacy, Minzu University of China, Beijing 100081, China;
    6 Beijing Union-Genius Pharmaceutical Technology Co.,Ltd, Beijing 100176, China
  • Received:2020-03-16 Revised:2020-06-22 Online:2020-05-15 Published:2020-05-13

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摘要： COVID-19的发病特征为发热、干咳、乏力,严重者可进展为急性呼吸窘迫综合征（ARDS）等,甚至危及生命。SARS-CoV-2可通过血管紧张素转化酶2（ACE2）入侵细胞并导致ACE2表达下调。ACE2表达下调会导致肾素-血管紧张素系统（RAS）的失衡,从而引起后续病理状态发生,RAS在ARDS中也发挥重要的作用。本文总结了RAS系统在COVID-19发病过程中可能存在的作用,以及基于RAS对于COVID-19的治疗可能,为优化治疗及后续研究提供参考。

关键词: COVID-19, 血管紧张素转化酶2, 肾素-血管紧张素系统, 肺损伤, 病理作用, 研究进展

Abstract: The pathogenesis of COVID-19 is characterized by fever, dry cough and fatigue. In severe cases, it may progress to acute respiratory distress syndrome (ARDS), etc., and even death. SARS-CoV-2 can invade cells through angiotensin-converting enzyme 2 (ACE2) and cause down-regulation of ACE2 expression. The down-regulation of ACE2 expression can lead to the imbalance of renin-angiotensin system (RAS), which leads to the occurrence of subsequent pathological states. RAS also plays an important role in ARDS. This review summarized the possible roles of RAS in the pathogenesis of COVID-19, as well as treatment of COVID-19 based on RAS, hoping to optimize the treatment and provide reference information.

Key words: COVID-19, angiotensin-converting enzyme 2, renin-angiotensin system, lung injury, pathological effects, research progress

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