中国药物警戒 ›› 2020, Vol. 17 ›› Issue (3): 143-147.
DOI: 10.19803/j.1672-8629.2020.03.03

• 临床研究 • 上一篇    下一篇

真实世界中阿奇霉素不同方案治疗儿童肺炎支原体肺炎的比较评价研究

苟静惠, 冉海龙, 奚鑫, 杜倩*   

  1. 重庆医科大学附属第三医院（捷尔医院）药剂科,重庆 401120
  • 收稿日期:2020-03-17 修回日期:2020-03-17 出版日期:2020-03-15 发布日期:2020-03-17
  • 通讯作者: *杜倩,博士,主管药师,临床药学。E-mail：duqian@hospital.cqmu.edu.cn
  • 作者简介:苟静惠,女,本科,药师,临床药学。

Evaluation of Azithromycin in Different Treatment Protocols on Pediatric Mycoplasma Pneumoniae Pneumonia

GOU Jinghui, RAN Hailong, XI Xin, DU Qian*   

  1. Department of Pharmacy, the Third Affiliated Hospital of Chongqing Medical University(Gener Hospital), Chongqing 401120,China
  • Received:2020-03-17 Revised:2020-03-17 Online:2020-03-15 Published:2020-03-17

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摘要： 目的 评估阿奇霉素不同治疗方案治疗儿童肺炎支原体肺炎的有效性、安全性和经济性。方法 检索2018年入住某三甲医院确诊为“肺炎支原体肺炎”且排除重症的220例患儿病例,据临床治疗方案分为两组。A组：阿奇霉素静脉滴注+头孢呋辛联用治疗组123例;B组：阿奇霉素静脉单药治疗组97例。比较两组患儿临床表现、住院时间及抗菌药物费用等情况。结果 两组患儿入院时一般资料比较差异无统计学意义（P>0. 05）,具有可比性。两组患儿治疗后临床症状发热、咳嗽持续时间、肺部啰音持续时间、住院时间、临床治疗有效率及不良反应发生率等差异无统计学意义（P>0.05）。抗菌药物费用、住院总费用等差异有统计学意义（P<0.05）。治疗方案的成本-效果比,B组明显低于A组。结论 阿奇霉素不同治疗方案治疗肺炎支原体肺炎具有相似的有效性和安全性,但阿奇霉素单药治疗的方案更具经济性。

关键词: 肺炎支原体肺炎, 阿奇霉素, 疗效, 成本

Abstract: Objective To evaluate the efficacy, safety and cost of azithromycin in the treatment of pediatric Mycoplasma pneumoniae pneumonia. Methods A total of 220 children with Mycoplasma pneumoniae pneumonia who were treated in a hospital in 2018 were selected. According to the treatment protocols, these patients were divided into two groups: group A that had 123 patients treated with azithromycin intravenous infusion plus cefuroxime and group B in which 97 patients received azithromycin intravenous monotherapy. The clinical manifestations, length of hospital stay and cost of antibiotics were compared between the two groups. Results There was no significant difference in the general data between the two groups (P>0.05). There was also no significant difference in the clinical symptoms of fever, duration of cough and lung rale, length of hospital stay, clinical effect, or incidence of adverse reactions between the two groups after treatment (P>0.05). However, there was statistically significant difference in the cost of antibiotics and the total cost of hospitalization (P<0.05), The cost-effectiveness ratio of treatment protocols in group B was significantly lower than that of group A. Conclusion Different treatment protocols of azithromycin have similar efficacy and safety in the treatment of pediatric Mycoplasma pneumoniae pneumonia, but azithromycin monotherapy regimens are more economical.

Key words: Mycoplasma pneumoniae pneumonia, azithromycin, effect, cost

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