Research progress in the role of NLRP3 inflammasome in neurodegenerative diseases and in treat-ments

doi:10.19803/j.1672-8629.20230154

Abstract

Abstract: Neurodegenerative diseases are serious health issues facing the world’s aging population, which are usually manifested as cognitive decline, loss of motor function and dementia. The pathogenesis of neurodegenerative diseases is complex, and current treatments for these diseases can do nothing more than control their symptoms. NLRP3 inflammasome, as the most studied inflammasome, is widely involved in neurodegenerative diseases. This article reviews the structure and function of NLRP3 inflammasome and its involvement in different neurodegenerative diseases before the progress in drug research related NLRP3 inflammasome in the treatment of neurodegenerative diseases is summarized.

Key words: NLRP3 inflammasome, neurodegenerative disease, Parkinson’s disease, Alzheimer’s disease

CLC Number:

R971
R744

MA Yidan, SHEN Xin, YANG Jun, YAN Jiaqing. Research progress in the role of NLRP3 inflammasome in neurodegenerative diseases and in treat-ments[J]. Chinese Journal of Pharmacovigilance, 2023, 20(11): 1316-1320.

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