Abstract: Objective To evaluate the effect of Jinzhen oral liquid (JOL) on a mouse model of pneumonia induced by influenza ( H1N1) FM1 strain and parainfluenza virus in order to provide reference for clinical applications. Methods Mice were randomly divided into the normal group, model group, JOL high-dose group ( 8 g· kg^-1·d^-1), JOL medium-dose group ( 4 g·kg^-1·d^-1 ), and JOL low-dose group ( 2 g·kg^-1·d^-1 ). Mice were infected via intranasal infection with influenza H1N1/FM1 or parainfluenza virus. Oseltamivir phosphate granules, ribavirin granules and Resuqing oral liquid were used as positive control drugs. Four days after the infection,the lung indexes,inhibition rate, pathological changes were observed．In the death protection experiment,the death rate within 14 days was analyzed．Results Compared with the model group, treatment with JOL could lower the lung indexes, alleviate pathological changes of the lung,and reduce mortality of mice. Conclusion JOL can effectively protect the mouse model from pneumonia induced by influenza H1N1/FM1 or parainfluenza virus.

Key words: Jinzhen oral liquid, influenza H1N1/FM1, parainfluenza virus, the lung index, lung tissue, oseltamivir phosphate granule, ribavirin granule, Resuqing oral liquid