Abstract: Objective To investigate the relationships between blood trough concentrations of vancomycin and medication regimens. Methods A total of 199 patients who received vancomycin and TDM services in our hospital between January 1, 2017 and February 28, 2020 were selected. According to the monitoring concentrations, they were divided into the low-trough concentration group (< 10 μg·mL^-1), through concentration group (10~20 μg·mL^-1) and high-through concentration group (>20 μg·mL^-1). The treatment regimens of the patients were evaluated according to the drug instructions/guidelines. Results Among the 199 patients, 45 (22.6%) were in the low-trough concentration group, 95 (47.7%) were in the trough concentration group, and 59 (29.7%) were in the high trough concentration group. Fifty-two (42.6%) of the 122 patients with correct dosage were in the trough concentration group. The trough concentrations of females were significantly higher than those of males ( P<0.001), and the trough concentration of the group under 18 years old was significantly lower than that of other groups (P<0.05). Conclusion More detailed guidelines and recommendations need to be formulated for initial administration according to patients’ age, gender, weight, renal function, drug combinations and complications. More vigorous monitoring of trough concentrations of vancomycin and adjustment of medications can enhance drug safety of patients.

Key words: vancomycin, dosing regimen, through concentration