Risk ranking and pharmacovigilance thinking of renal injury induced by traditional Chinese medicine with acrid, hot and toxic properties

doi:10.19803/j.1672-8629.2022.05.03

Abstract

Abstract: Objective Taking the renal target organs as the entry point, to establish a graded model of renal injury risk with the example of traditional Chinese medicine with acrid, hot and toxic properties. And corresponding pharmacovigilance was carried out according to this model. Methods A semi-qualitative and quantitative three-dimensional matrix risk ranking model for renal injury was established by collecting case reports of adverse drug reactions (ADR) induced by traditional Chinese medicine with acrid, hot and toxic properties from CNKI, VIP and WanFang database from construction to December 31, 2021, and using a spatial distance model from the three-dimensional perspective of drugs, patients and clinical medication. Results Based on the case reports of traditional Chinese medicine with acrid, hot and toxic properties Caowu (Aconiti Kusnezoffii Radix), Banmao (Mylabris), Xionghuang (Realgar), Wugong (Scolopendra) and Cangerzi (Xanthii Fructus) included in this paper, a three-dimensional evaluation of the toxicity of drug toxicity, the patient's original kidney-related disease and the patient's clinical use of the drug preparation, dose, medication compliance, drug combination and route of administration was conducted to assign a risk rating to different cases, and cautionary measures of contraindication and prohibition could be applied respectively according to the risk evaluation level. Conclusion The risk ranking system of kidney injury induced by toxic Chinese medicine realizes the assessment and rank, which can provide reference for clinical drug evaluation, and realize targeted pharmacovigilance measures.

Key words: kidney injury, risk ranking, herbs with acrid,hot and toxic properties, pharmacovigilance, Caowu (Aconiti Kusnezoffii Radix), Banmao (Mylabris), Xionghuang (Realgar), Wugong (Scolopendra), Cangerzi (Xanthii Fructus)

CLC Number:

WU Huanzhang, ZHANG Xiaomeng, ZHANG Bing, LIN Zhijian, ZHANG Zhiqi1, ZHANG Yongqiang. Risk ranking and pharmacovigilance thinking of renal injury induced by traditional Chinese medicine with acrid, hot and toxic properties[J]. Chinese Journal of Pharmacovigilance, 2022, 19(5): 481-485.

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