Research progress in effects of lopinavir / ritonavir used by lactating females on sucklings

doi:10.19803/j.1672-8629.2022.03.14

Abstract

Abstract: Lopinavir / ritonavir has been approved for the treatment of human immunodeficiency virus (HIV) infection in China. It is also listed as an effective antiviral drug amid the COVID-19 pandemic in China. Lactating women infected with COVID-19 will have to face the problem of which antiviral drugs should be selected during lactation. This paper was intended to summarize the pharmacokinetics of lopinavir / ritonavir, the concentrations of lopinavir / ritonavir in breast milk and in sucklings in the real world, the effect on sucklings, and the evidence related to the use of lopinavir / ritonavir in some infants. Lopinavir / ritonavir is a quite safe antiviral drug for lactating women, and its effect on sucklings is very small. If lopinavir / ritonavir has to be used in lactating women infected with the COVID-19 virus, suckling can be continued as long as the virus will not be transmitted vertically through suckling. The levels of serum sodium, serum potassium, cholesterol, triglyceride, blood glucose, alanine transaminase and insulin in sucklings should be monitored.

Key words: lopinavir / litonavir, COVID-19, sucklings, safety, HIV

CLC Number:

R994.11

ZHOU Boya, YUAN Sisi, FENG Xin. Research progress in effects of lopinavir / ritonavir used by lactating females on sucklings[J]. Chinese Journal of Pharmacovigilance, 2022, 19(3): 296-301.

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