Abstract: Objective To study the effect of Qingre Sanjie capsules on the animal model of bacterial respiratory tract infections in order to provide reference for clinical application. Methods Laboratory animals were randomly divided into 7 groups according to body weight: normal group, model group, amoxicillin capsule group, andrographolide dropping pill group and 3 different-dose groups of Qingre Sanjie capsules. Four animal models were established, including three models of pneumonia caused by staphylococcus aureus, beta hemolytic streptococcus and streptococcus pneumoniae infection in mice and one acute pharyngitis model induced by beta hemolytic streptococcus in rats. The lung index, lung index inhibition rate, mouse mortality, the average survival time, pharyngeal lesion scores of rats and pathological examination were used to evaluate the efficacy of Qingre Sanjie capsules against respiratory bacterial infections. Results Qingre Sanjie capsules at the three doses could significantly reduce the mortality, prolong the average survival time, alleviate the pharyngeal lesions of mice infected with beta-hemolytic streptococcus, and reduce the lung index of mice infected with streptococcus pneumonia. Conclusion All the three doses of Qingre Sanjie capsules could effectively alleviate the symptoms of acute pharyngitis caused by beta-hemolytic streptococcus. They also have significant antibacterial effect in vivo.

Key words: bacterial respiratory tract infection, acute pharyngitis, Qingre Sanjie capsule, beta-hemolytic streptococcus