Abstract: Objective To investigate the stability of rifampin in six solvents. Methods After the samples of rifampin were dissolved in six solvents, RP-HPLC was employed to analyze the contents at different time and temperature. Results The concentration of rifampin had no significant change in 0.9% NS and 5% GS with the volume of 500 mL. However, the decline of the content of rifampinin was observed with increased temperature and extended time. Conclusion It may be beneficial to make up rifampin in 0.9% NS and 5% GS with the volume of 500 mL.

Key words: rifampin, solvent, compatible stability