Clinical Efficacy of Thioctic Acid Injection in Diabetic Patients with Cerebral Infarction and Its Influence on Serum Inflammatory Cytokines Level

Abstract

Abstract: Objective To investigate the clinical effect of thioctic acid injection and the expression changes of the inflammatory cytokines soluble intercellular adhesion molecule-1 (sICAM-1) and interleukin-6 (IL-6) in patients with type 2 diabetes and cerebral infarction. Methods 138 cases of type 2 diabetes with cerebral infarction in our hospital from January 2012 to May 2014 were randomly divided into control group (conventional treatment) and treatment group (treated with thioctic acid injection). The total effective rates, neurological function, activity of daily living, expression levels of inflammatory cytokines of two groups were compared. Results The total effective rate of treatment group (91.30%) was significantly higher than that of control group (75.36%) (P<0.05). The values of activity of daily living were higher in treatement group compared with the control group (P<0.05), the neurological severity score was lower in treatment group compared with the control group (P<0.05). Compared with the control group, the concentration of sICAM-1 and IL-6 decreased significantly, the differences of them were statistically significant (P<0.01). Conclusion Thioctic acid injection for the treatment of type 2 diabetes with cerebral infarction has a significant clinical effect. It can improve patients’ neurological function, attenuate inflammatory response.

Key words: thioctic acid injection, type 2 diabetes, cerebral infarction, interleukin-6, clinical efficacy

CLC Number:

R969.4

FENG Jing, ZHENG Hu-lin. Clinical Efficacy of Thioctic Acid Injection in Diabetic Patients with Cerebral Infarction and Its Influence on Serum Inflammatory Cytokines Level[J]. Chinese Journal of Pharmacovigilance, 2016, 13(6): 330-332.

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