苓桂术甘汤的现代临床应用与分析

doi:10.19803/j.1672-8629.2021.11.15

摘要/Abstract

摘要： 目的了解苓桂术甘汤现代临床应用概况和优势病种,为经典名方苓桂术甘汤复方制剂开发和临床应用提供参考,也为其他经典名方现代临床应用分析分享思路。方法检索1979年1月1日至2020年2月11日中国知网、维普网、万方数据等数据库相关文献,并用Excel 2010对主治病症、病例数、药味组成、组方特点、药味剂量、用法用量、有效率和不良反应等关键信息整理、统计,从数据角度阐明苓桂术甘汤临床概况和优势病种,并对优势病种分析。结果符合要求的现代临床文献共计543篇,发现苓桂术甘汤在现代临床应用方面呈现主治病症较多、病例数多集中50~99例、药味组成以加味为主、总有效率超90%、药品不良反应少等特点;心力衰竭为苓桂术甘汤现代临床优势病种之一,心力衰竭治疗方表现药味组成仍然基于原方,药味剂量多样,以茯苓（30、15、20 g）,桂枝（10、15、6 g）,白术（15、10、20 g）,甘草（6、10、3 g）常见;服用方法为水煎煮,每日1剂,分2~3次服,每次100~200 mL;组方规律以加减益气、活血、利水药味进行配伍。结论本文通过对苓桂术甘汤现代临床应用概况和优势病种进行分析,可以为其研制提供临床资料,指导其产业化的临床应用。

关键词: 经典名方, 苓桂术甘汤, 现代临床, 优势病种, 心力衰竭

Abstract: Objective To find out about the clinical profiles and targeted diseases of Linggui Zhugan decoction in order to provide reference for the development and application of Linggui Zhugan decoction and to inspire ideas for modern clinical applications of other classical prescriptions. Methods Related literature that was published between January 1, 1979 and February 11, 2020 was searched for from CNKI, VIP, Wanfang and other databases, Excel 2010 was used to sort out and statistically analyze such key information as the indications, number of cases, composition of medicine, characteristics of prescriptions, dosage, usage, efficacy and adverse reactions. The clinical applicability and targeted diseases of Linggui Zhugan decoction were studied based on data. Results A total of 543 pieces of literature met the inclusion criteria. It was found that Linggui Zhugan decoction was used against various indications, the number of cases ranged from 50 to 99, the total effective rate was over 90% and that few adverse reactions occurred. Heart failure was one of the targeted diseases of this decoction and the composition of this decoration was still based on the original prescription. The dosage varied considerably. This decoration was prepared by boiling the ingredients in water. 100-200 mL was taken each time, two or three times a day. Other herbs, which could benefit qi, activate blood and facilitate urination, were added. Conclusion This paper is expected to provide clinical data for more extensive use of Linggui Zhugan decoction and guide its industrialized clinical application.

Key words: classical formulas, Linggui Zhugan decoction, modern clinical practice, targeted diseases, heart failure

中图分类号:

R924

王璐瑶, 邓哲, 肖苏萍, 张权, 欧阳罗丹, 陈蒙, 周海燕, 王继永, 杜杰. 苓桂术甘汤的现代临床应用与分析[J]. 中国药物警戒, 2021, 18(11): 1066-1069.

WANG Luyao, DENG Zhe, XIAO Suping, ZHANG Quan, OUYANG Luodan, CHEN Meng, ZHOU Haiyan, WANG Jiyong, DU Jie. Modern Clinical Applications and Analysis of Linggui Zhugan Decoction[J]. Chinese Journal of Pharmacovigilance, 2021, 18(11): 1066-1069.

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