Chinese Journal of Pharmacovigilance ›› 2021, Vol. 18 ›› Issue (5): 478-482.
DOI: 10.19803/j.1672-8629.2021.05.16

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Analysis of Adverse Drug Reactions Induced by SGLT-2 Inhibitors

ZHANG Houjing1,2, JI Liwei1,*   

  1. 1Department of pharmacy, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Geriatric, Beijing 100730 China;
    2Department of pharmacy, Xiamen Cardiovascular Hospital Xiamen University, Xiamen Fujian 361000, China
  • Received:2019-12-23 Online:2021-05-15 Published:2021-05-12

Abstract: Objective To explore the characteristics and regularity of adverse drug reactions(ADR) induced by SGLT-2 inhibitors, so as to improve the safety of clinical medication. Methods CNKI, WanFang, VIP, PubMed, Embase and Medline database were retrieved from database building to November 28, 2019 and ADR induced by SGLT-2 inhibitors were analyzed retrospectively. Results A total of 40 cases of ADR induced by SGLT-2 inhibitors was enrolled in this study. Among them, 13 ADR were involved, and the top 3 types of ADR induced by SGLT-2 inhibitors were diabetic ketoacidosis (55.0%), acute pancreatitis (10.0%), fanconi syndrome (7.5%). Conclusion ADR induced by SGLT-2 inhibitors were varied, in which more attentions should be paid to new ADR such as fanconi syndrome, sweet syndrome and so on. During application of SGLT-2 inhibitors, the indications should be strict and close monitoring was necessary.

Key words: SGLT-2 inhibitors, adverse drug reactions, analysis

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