中国药物警戒 ›› 2021, Vol. 18 ›› Issue (4): 365-367.
DOI: 10.19803/j.1672-8629.2021.04.15

• 安全与合理用药 • 上一篇    下一篇

华法林致药物性肝损伤报告分析

吴婷, 吕小琴*   

  1. 浙江省药品化妆品审评中心,浙江 杭州 310012
  • 收稿日期:2019-12-10 出版日期:2021-04-15 发布日期:2021-04-23
  • 通讯作者: *吕小琴,女,硕士,副主任药师,药理学。E-mail: 79854875@qq.com
  • 作者简介:吴婷,女,硕士,药品不良反应监测。

Drug-induced Liver Injury Caused by Warfarin

WU Ting, LYV Xiaoqin*   

  1. Zhejiang Center for Adverse Drug Reaction Monitoring, Hangzhou Zhejiang 310012, China
  • Received:2019-12-10 Online:2021-04-15 Published:2021-04-23

摘要: 目的 分析浙江省华法林在临床使用中导致的药物性肝损伤(DILI)的特点,为临床合理用药提供参考。方法 针对2010年1月1日至 2019年8月31日期间国家药品不良反应监测系统浙江省平台收集到的华法林相关不良反应报告进行统计,分析怀疑使用华法林导致的肝胆系统损伤的不良反应报告。结果 27例华法林导致DILI病例,女性患者是男性的2倍,年龄主要集中在45岁以上(92.3%)。结论 华法林导致的DILI在临床上应引起注意,尤其与其他药品合用时应慎重考虑,避免联用易致肝毒性的药物。建议在治疗过程中加强华法林用药监护,定期检查肝功能。

关键词: 华法林, 药品不良反应, 药物性肝损伤

Abstract: Objective To analyze the characteristics of drug-induced liver injury (DILI) caused by warfarin in Zhejiang Province so as to provide reference for clinical rational drug use. Methods Data on warfarin-caused adverse drug reactions (ADR), especially DILI, that was collected by the Zhejiang Provincial Platform of the national adverse drug reactions monitoring database from January 1, 2010 to August 31, 2019 was analyzed statistically. Results There were 27 cases of DILI caused by warfarin. There were twice as many female patients as male ones, and most of the patients were over 45 years old (92.3%). Conclusion The DILI caused by warfarin deserves attention in clinical practice when it is used together with other drugs, especially those that are likely to cause hepatotoxicity. It is recommended that warfarin be used with caution and liver function be checked regularly.

Key words: warfarin, adverse drug reaction, drug induced liver injury

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