中国药物警戒 ›› 2020, Vol. 17 ›› Issue (4): 227-230.
DOI: 10.19803/j.1672-8629.2020.04.07

• 安全与合理用药 • 上一篇    下一篇

喹诺酮类药物致血小板减少不良反应文献分析

常馨予, 郭桂明*   

  1. 首都医科大学附属北京中医医院临床药学科,北京 100010
  • 收稿日期:2019-06-12 修回日期:2020-06-28 出版日期:2020-04-15 发布日期:2020-04-10
  • 通讯作者: *郭桂明,男,主任药师,临床药学与药事管理。E-mail：ggmjq@sina.com
  • 作者简介:常馨予,女,主管药师,临床药学。

Literature Review of Adverse Drug Reactions of Quinolones-induced Thrombocytopenia

CHANG Xinyu, GUO Guiming*   

  1. Department of Clinical Pharmacy, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010, China
  • Received:2019-06-12 Revised:2020-06-28 Online:2020-04-15 Published:2020-04-10

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摘要： 目的 分析喹诺酮类药物左氧氟沙星和莫西沙星引起药物性血小板减少病例及其临床特点,为临床安全用药提供参考。方法 通过检索PubMed、Medline数据库、中国学术期刊全文数据库、维普中文科技期刊数据库,搜集喹诺酮类药物左氧氟沙星和莫西沙星致血小板减少的不良反应个例报道,并对患者性别、年龄以及基础疾病、合并用药、给药途径、临床表现以及预后情况进行统计分析。结果 共搜集10例使用左氧氟沙星和6例使用莫西沙星后发生了血小板减少的不良反应病例报道。62.5%该类不良反应发生在60岁以上高龄患者;68.75%病例有高血压、糖尿病等基础慢性疾病史;除1例患者死亡外,其余患者在停药后5~40天内转归,不良反应类型为严重药品不良反应。结论 喹诺酮类药物引起血小板减少不良反应的报道较少,但后果较严重,临床应用应早期及时监测,并及时给予对症处理。

关键词: 喹诺酮类药物, 血小板减少, 药品不良反应, 文献分析

Abstract: Objective To analyze the clinical characteristics of thrombocytopenia caused by quinolones, levofloxacin and moxifloxacin so as to provide reference for clinical safe drug use. Methods By searching PubMed, Medline, CNKI database and VIP Chinese full-text database, case reports of adverse drug reactions of thrombocytopenia induced by levofloxacin and moxifloxacin were retrieved. The patients' gender, age, underlying diseases, combined medication, routes of administration, clinical manifestations and prognosis were also analyzed statistically. Results Totally 10 patients with thrombocytopenia induced by levofloxacin and 6 patients by moxifloxacin were collected. Statistics showed that 62.5% of these adverse reactions occurred in patients over 60 years old. 68.75% of the cases had a history of such preexisting chronic diseases as hypertension and diabetes mellitus. Except for one patient who died, the conditions of other patients improved within 5~40 days of withdrawal. The adverse reactions of this type were severe. Conclusion There are few reports of adverse drug reactions of thrombocytopenia caused by quinolones, but the consequences are serious. Clinical application should be monitored as soon as possible for the sake of symptomatic treatment.

Key words: quinolone, thrombocytopenia, adverse drug reactions, literature analysis

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