中国药物警戒 ›› 2020, Vol. 17 ›› Issue (4): 214-220.
DOI: 10.19803/j.1672-8629.2020.04.05

• 基础研究 • 上一篇    下一篇

桂枝茯苓组方的网络药理学研究

杨书彬1, 裴晨晨1,2, 师伟3, 王信3, 李娜4, 曹广尚3, 张海鸣2, 聂颖兰2, 孙健2*   

  1. 1 黑龙江中医药大学,黑龙江 哈尔滨 150040;
    2 中国中医科学院医学实验中心,道地药材国家重点实验室培育基地,北京 100700;
    3 山东中医药大学附属医院,山东 济南 250011;
    4 山东中医药大学,山东 济南 250355
  • 收稿日期:2020-01-10 修回日期:2020-06-28 出版日期:2020-04-15 发布日期:2020-04-10
  • 通讯作者: *孙健,男,博士,研究员,中药物质基础及活性机制研究。E-mail:sunjiankw@163.com
  • 作者简介:杨书彬,男,博士,副教授,中药质量评价及活性研究。
  • 基金资助:
    国家自然科学基金资助项目(81102672); 中央级公益性科研院所基本科研业务费专项资金(ZZ2019003); 中央级公益性科研院所基本科研业务费专项资金(ZZ2015016); 国家重点实验室培育项目(PTSJ2018002)

Network Pharmacology Study of Chinese Medicine Guizhifuling Formulae

YANG Shubin1, PEI Chenchen1,2, SHI Wei3, WANG Xin3, LI Na4, CAO Guangshang3, ZHANG Haiming2, NIE Yinglan2, SUN Jian2*   

  1. 1 Heilongjiang University Of Chinese Medicine, Harbin Heilongjiang 150040, China;
    2 State Key Laboratory Breeding Base of Dao-di Herbs, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China;
    3 Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan Shandong 250355, China;
    4 Shandong University of Traditional Chinese Medicine, Jinan Shandong 250355, China
  • Received:2020-01-10 Revised:2020-06-28 Online:2020-04-15 Published:2020-04-10

摘要: 目的 基于网络药理学研究桂枝茯苓组方治疗疾病的主要活性成分及潜在靶点。方法 从BATMAN-TCM数据库提取桂枝、茯苓、牡丹皮、白芍、桃仁的化学成分,以Score≥48和P≤0.05筛选活性成分及作用靶点,分析靶点富集的信号通路与疾病,构建药材-成分-靶点-通路网络,分析桂枝茯苓组方治疗疾病的药理作用机制。结果 获得虫草素、苯乙烯、茯苓酸、肉桂醛、肉桂酸等活性成分以及ADORA1、ADORA2A、HTR1B、CHRM2、CHRM4等核心靶点。主要治疗神经系统、心血管系统、生殖系统等三类疾病,包括疼痛、偏头痛、高血压、心脏衰竭、心率失常、前列腺增生症、勃起功能障碍、子宫内膜癌、子宫内膜异位症等,另外发现该组方具有治疗抑郁症、精神分裂、酒精依赖、阿尔茨海默病、药物依赖等疾病的潜在疗效。结论 通过网络药理学方法研究桂枝茯苓组方的多成分、多靶点药理学机制,为该组方的临床应用和开发提供新的思路。

关键词: 桂枝茯苓组方, 网络药理学, BAT-MAN TCM数据库, 药理机制

Abstract: Objective To study the main active ingredients and potential targets of Guizhifuling formulae for treatment diseases based on network pharmacology. Methods The chemical constituents of ramulus cinnamom poria, tree peony bark, radix paeoniae alba and peach seed were extracted from the BATMAN-TCM database. The active ingredients and target targets were screened with scores ≥48 and P≤0.05, and the signal pathways and diseases of target enrichment were analyzed to establish a medicinal material-target-pathway network and analyze the pharmacological action mechanism of Guizhifuling formulae for treating diseases. Results Core targets such as ADORA1, ADORA2A, HTR1B, CHRM2, CHRM4 and other active ingredients such as Cordycepin, Styrene, Pachymic acid, Cinnamaldehyde, trans-Cinnamic acid were obtained. Mainly treats three types of diseases including nervous system, cardiovascular system and reproductive system, including pain, migraine, hypertension, heart failure, arrhythmia, benign prostatic hyperplasia, erectile dysfunction, endometrial cancer, endometriosis et al. In addition, this formulae was found to have potential therapeutic effects in the treatment of depression, schizophrenia, alcohol dependence, Alzheimer's disease and drug dependence. Conclusion Studying multi-component, multi-target pharmacological mechanism of Guizhifuling formulae through the network pharmacology method provides new ideas for clinical application and development of this prescriptions.

Key words: Guizhifuling formulae, network pharmacology, BAT-MAN TCM database, pharmacological mechanism

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