One Case of Toxic Epidermal Necrolysis Induced by Antibacterial Drugs
LUO Xiaofeng1, DU Qian2, XI Xin2, RAN Hailong2,*
1School of Pharmacy, Chongqing Medical University, Chongqing 400016, China; 2Department of Pharmacy, the Third Affiliated Hospital of Chongqing Medical University(Gener Hospital), Chongqing 401120, China
Abstract：Objective To remind the medical staff to pay close attention to medication safety of antibacterial drugs. Methods One case of toxic epidermal necrolysis (TEN) after intravenous infusion of piperacillin tazobactam, imipenem/cilastatin, and levofloxacin in a 45-year-old male patient was analyzed while literature about the pathogenesis and treatment of TEN was reviewed. Results Toxic epidermal necrolysis was most likely to be induced by piperacillin tazobactam, imipenem/cilastatin, and levofloxacin in this patient. The symptoms on the patient's skin were relieved gradually via timely discontinuation of the drugs, anti-allergic therapy, systemic immunotherapy, and symptomatic supportive treatment. Conclusion Toxic epidermal necrolysis induced by piperacillin tazobactam, imipenem/cilastatin, and levofloxacin is a disease with low incidence, but with a high mortality and poor prognosis, which deserves attention.
罗晓枫, 杜倩, 奚鑫, 冉海龙. 抗菌药物致中毒性表皮坏死松解症1例[J]. 中国药物警戒, 2020, 17(8): 535-538.
LUO Xiaofeng, DU Qian, XI Xin, RAN Hailong. One Case of Toxic Epidermal Necrolysis Induced by Antibacterial Drugs. Chinese Journal of Pharmacovigilance, 2020, 17(8): 535-538.
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2020, Vol. 17 
