Abstract：Objective explore and analyze the regularities and characteristics of skin systemic adverse reactions induced by clopidogrel so as to provide reference for safe clinical drug use. Methods The Cochrane library, PubMed, Web of Science, Springer link, Embase, Scopus, CNKI, Wanfang data, VIP database, Chinese biomedical literature database (CBM) and other database at home and abroad were searched and related articles were retrieved. Those on skin reactions induced by clopidogrel were statistically analyzed. Results A total of 15 patients with skin systemic adverse reactions induced by clopidogrel were collected, including 11 patients aged over 60 years old (73.3%). The shortest time to onset occurred within 30 minutes after administration, the longest occurred 310 days after clopidogrel use. Adverse reactions were manifested as pruritus of different degrees, including one patient with low fever and another one with high fever. The adverse reactions were alleviated until they disappeared after patients stopped taking clopidogrel or started taking other therapeutic drugs. Conclusion Pharmaceutical care should be strengthened in clinical use of clopidogrel, the occurrence of adverse skin reactions should be guarded against, and the risk of re-administration should be cautiously assessed.
王迪, 张永凯, 李楠, 李艳娇. 氯吡格雷致皮肤不良反应文献分析[J]. 中国药物警戒, 2020, 17(8): 531-534.
WANG Di, ZHANG Yongkai, LI Nan, LI Yanjiao. Literature Review of Adverse Skin Reactions Induced by Clopidogrel. Chinese Journal of Pharmacovigilance, 2020, 17(8): 531-534.
2020, Vol. 17 
