双氯芬酸钠盐酸利多卡因药品不良反应/事件分析

doi:10.19803/j.1672-8629.2020.08.12

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摘要目的分析双氯芬酸钠盐酸利多卡因药品不良反应/事件的发生特点及规律,为临床安全合理使用提供依据。方法回顾性分析宁夏某三甲医院上报的10例及文献报道8例双氯芬酸钠盐酸利多卡因药品不良反应/事件报告,对报告的类别、患者性别、年龄、既往史、过敏史、用药原因、发生时间、转归、累及系统-器官以及临床表现等进行综合分析。结果已上报的双氯芬酸钠盐酸利多卡因致药品不良反应/事件显示：呼吸系统和皮肤及其附件损害最为常见；既往有哮喘史患者用药后诱发哮喘急性发作的占比高；严重药品不良反应/事件占比较高，死亡患者占比较高；发生不良反应/事件与用药时间间隔较短；超说明书用药情况较为普遍。结论加强双氯芬酸钠盐酸利多卡因的合理使用和监测，避免严重不良反应/事件的发生，保障患者的用药安全。

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	吴文利
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	王基云
	王晓旭

关键词 ：双氯芬酸钠盐酸利多卡因, 药品不良反应, 药品不良事件

Abstract：Objective To investigate the characteristics and regularities of adverse drug reactions/events (ADR/AE) induced by diclofenac sodium and lidocaine hydrochloride so as to provide reference for rational clinical use. Methods The data on 10 cases of ADR/AE induced by diclofenac sodium and lidocaine hydrochloride reported by a tertiary hospital in Ningxia Hui Autonomous Region and 8 cases from literature was analyzed retrospectively. The types of reports, gender, age, medical history, allergies, indications, times of occurrence, prognosis, systems or organs involved and clinical manifestations were analyzed. Results It was shown that the respiratory system and skin and its appendages were the most vulnerable. Patients with a previous asthma history had a high incidence of acute attack of asthma after medication. There were more severe cases of ADR/AE and death. ADRs occurred soon after administration of diclofenac sodium and lidocaine hydrochioride. Off-label drug use was commonplace. Conclusion The monitoring and rational use of diclofenac sodium and lidocaine hydrochloride should become a concern in order to prevent serious ADR/AE and ensure the safety of drug use.

Key words： diclofenac sodium and lidocaine hydrochioride adverse drug reactions(ADR) adverse drug events(AE)

收稿日期: 2020-07-31

PACS:

R994.11

作者简介: 吴文利,女,硕士,主管药师,临床药学及医院药品不良反应监测。E-mail:459974841@qq.com

引用本文:

吴文利, 刘佳妮, 陆钊罡, 景晶, 王健, 王基云, 王晓旭. 双氯芬酸钠盐酸利多卡因药品不良反应/事件分析[J]. 中国药物警戒, 2020, 17(8): 508-512.
WU Wenli, LIU Jiani, LU Zhaogang, JIN jing, WANG Jian, WANG Jiyun, WANG Xiaoxu. Cases of Adverse Drug Reactions/events Induced by Diclofenac Sodium and Lidocaine Hydrochloride. Chinese Journal of Pharmacovigilance, 2020, 17(8): 508-512.

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http://www.zgywjj.com/CN/10.19803/j.1672-8629.2020.08.12 或 http://www.zgywjj.com/CN/Y2020/V17/I8/508

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