Cases of Adverse Drug Reactions/events Induced by Diclofenac Sodium and Lidocaine Hydrochloride
WU Wenli1, LIU Jiani2, LU Zhaogang1, JIN jing1, WANG Jian1, WANG Jiyun1, WANG Xiaoxu1
1Department of Clinical Pharmacy, People's Hospital of Ningxia Hui Autonomous Region /First Affiliated Hospital of Northwest University for Nationalities, Yinchuan Ningxia 750021, China; 2Department of Rehabilitation Medicine, People's Hospital of Ningxia Hui Autonomous Region/First Affiliated Hospital of Northwest University for Nationalities, Yinchuan Ningxia 750021, China
Abstract:Objective To investigate the characteristics and regularities of adverse drug reactions/events (ADR/AE) induced by diclofenac sodium and lidocaine hydrochloride so as to provide reference for rational clinical use. Methods The data on 10 cases of ADR/AE induced by diclofenac sodium and lidocaine hydrochloride reported by a tertiary hospital in Ningxia Hui Autonomous Region and 8 cases from literature was analyzed retrospectively. The types of reports, gender, age, medical history, allergies, indications, times of occurrence, prognosis, systems or organs involved and clinical manifestations were analyzed. Results It was shown that the respiratory system and skin and its appendages were the most vulnerable. Patients with a previous asthma history had a high incidence of acute attack of asthma after medication. There were more severe cases of ADR/AE and death. ADRs occurred soon after administration of diclofenac sodium and lidocaine hydrochioride. Off-label drug use was commonplace. Conclusion The monitoring and rational use of diclofenac sodium and lidocaine hydrochloride should become a concern in order to prevent serious ADR/AE and ensure the safety of drug use.
吴文利, 刘佳妮, 陆钊罡, 景晶, 王健, 王基云, 王晓旭. 双氯芬酸钠盐酸利多卡因药品不良反应/事件分析[J]. 中国药物警戒, 2020, 17(8): 508-512.
WU Wenli, LIU Jiani, LU Zhaogang, JIN jing, WANG Jian, WANG Jiyun, WANG Xiaoxu. Cases of Adverse Drug Reactions/events Induced by Diclofenac Sodium and Lidocaine Hydrochloride. Chinese Journal of Pharmacovigilance, 2020, 17(8): 508-512.