Abstract：Since the outbreak of SARS-CoV-2, research on antiviral drugs has continued. Arbidol is a broad-spectrum antiviral drug mainly used for anti-influenza. The success of the vitro cell test on SARS-CoV-2 attracted clinical attention and arbidol began to be used in the treatment of COVID-19. However, because of our limited knowledge of the pharmacological mechanism, clinical application evaluation and pharmaceutical care of arbidol, its clinical use was limited. Based on the relevant literature and reference at home and abroad, this paper summarizes the basic information of arbidol, the pharmacological basis of treating viral diseases with arbidol, the application and evaluation of arbidol against viral diseases in order to provide reference for the safe and effective use of arbidol in the treatment of COVID-19.
庞文渊, 王乔宇, 赵志刚. 阿比多尔治疗病毒性疾病的应用及评估[J]. 中国药物警戒, 2020, 17(6): 321-325.
PANG Wenyuan, WANG Qiaoyu, ZHAO Zhigang. Application and Evaluation of Arbidol in Treating Viral Diseases. Chinese Journal of Pharmacovigilance, 2020, 17(6): 321-325.
[1] 李洋, 赵立. 阿比多尔抗呼吸道病毒的药理作用与体外和体内疗效研究现状[J]. 中国临床药理学杂志, 2019, 35(17): 1964-1968. [2] 张菊, 方峰. 非核苷类抗病毒药物阿比多尔的研究进展[J]. 中国循证儿科杂志, 2011, 6(4): 308-312. [3] 陈致雯, 卢焯明. 阿比多尔颗粒治疗儿童流行性感冒疗效观察[J].现代中西医结合杂志, 2014, 23(14): 1528-1529. [4] 周一平,蒋景仪,陈四艳, 等.阿比朵尔对小鼠的免疫调节作用[J].医药导报,2005,24(11):989-991. [5] Blaising J, Polyak SJ, Pecheur EI.Arbidol as a broad-spectrum antiviral: an update[J]. Antiviral research, 2014, 107(1):84-94. [6] Shi L, Xiong H, He J, et al.Antiviral activity of arbidol against influenza A virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirusin vitroandin vivo[J]. 2007,152(8): 1447-1455. [7] Fung TS, Liu DX.Human Coronavirus: Host-Pathogen Inter-action[J]. Annual Review of Microbiology, 2019(73): 529-557. [8] 纪晓光, 赵艳红, 张敏, 等. 阿比多尔抗SARS病毒的体外实验研究[J]. 解放军药学学报, 2004,20(4): 274-276. [9] Khamitov RA, Loginova SY, Shchukina VN, et al.Antiviral activity of arbidol and its derivatives against the pathogen of severe acute respiratory syndrome in the cell cultures[J]. Voprosy Virusologii, 2008, 53(4): 9-13. [10] 关文达,杜秋伶,江海明,等.阿比多尔与连花清瘟胶囊对中东呼吸综合征冠状病毒的体内外抑制作用比较[J].广东医学,2018,39(23):3454-3458. [11] Gralinski LE, Menachery VD.Return of the Coronavirus: 2019-nCoV[J]. Viruses, 2020, 12(2): 135. [12] 王戎飞. 刚刚,李兰娟团队发布重大研究成果！两种药物效果显著！[EB/OL].(2020-02-03)[2020-03-25].https://mp.weixin.qq.com/s/tK_S7plFzFtHs3SJAgREug. [13] 国家卫生健康委员会,国家中医药管理局办公室. 新型冠状病毒肺炎诊疗方案(试行第六版)[EB/OL].(2020-02-18)[2020-03-25].http://www.nhc.gov.cn/yzygj/s7653p/202002/8334a8326 dd94d329df351d7da8aefc2.shtml. [14] 杜小兵, 刘双, 温林芳, 等. 阿比多尔片治疗流行性感冒有效性和安全性的开放性临床试验研究[J]. 心肺血管病杂志,2017, 36(7): 518-520. [15] 刘宏博, 曲文秀, 李胜岐, 等. 盐酸阿比朵尔片治疗流行性感冒的多中心随机双盲平行对照临床研究[J].中国临床药理学杂志,2006,22(6):403-405. [16] Wang MZ, Cai BQ, Li LY, et al.Efficacy and safety of arbidol in treatment of naturally acquired influenza[J]. Acta Academiae Medicinae Sinicae, 2004, 26(3): 289-293. [17] 曹瑜. 盐酸阿比多尔片在治疗急性呼吸道病毒感染中的安全性与有效性观察[J]. 中国现代药物应用, 2018, 12(17): 101-103. [18] Shuster AM, Shumilov VI, Shevtsov VA, et al.[Arbidol used in the prophylaxis of acute respiratory viral infections and their complications in servicemen][J]. 2004, 325(9): 44-45, 80. [19] 赵瑞玲, 张占慧, 张冠东. CFDA发布的药品不良反应信息通报中儿童用药典型病例分析[J].中国药物警戒,2018,15(2): 121-124. [20] Drinevskii VP, Osidak LV, Natsina VK, et al.Chemotherapeutics for treatment of influenza and other viral respiratory tract infec-tions in children[J]. Antibiot Khimioter, 1998, 43(9): 29-34. [21] 谢福政. 阿比多尔佐治病毒性肺炎100例[J]. 大家健康(学术版), 2014, 8(12): 147. [22] Semenenko TA, Sel'kova EP, Gotvianskaia TP, et al. Character-istics of the immune status in specific and nonspecific prophylaxis of influenza in elderly persons[J]. Zh Mikrobiol Epidemiol Immu-nobiol, 2005 (6): 24-28. [23] Wang Y, Chen X, Li Q, et al.Metabolite identification of arbidol in human urine by the study of CID fragmentation pathways using HPLC coupled with ion trap mass spectrometry[J]. Journal of mass spectrometry : JMS, 2008, 43(8): 1099-1109. [24] 李璐,陈娜,孔丽敏,等.新型冠状病毒感染特殊人群的抗病毒药物治疗方案[J].中国现代应用药学,2020,37(3):257-263. [25] 刘晓. 盐酸阿比朵尔药代动力学研究[D].沈阳药科大学,2009.[26] Song JH, Fang ZZ, Zhu LL, et al. Glucuronidation of the broad-spectrum antiviral drug arbidol by UGT isoforms[J]. The Journal of pharmacy and pharmacology, 2013, 65(4): 521-527. [27] Liu X, Huang T, Chen JX, et al.Arbidol exhibits strong inhibition towards UDP-glucuronosyltransferase (UGT) 1A9 and 2B7[J]. Pharmazie, 2013, 68(12): 945-950. [28] Wang Z, Yang B, Li Q, et al. Clinical Features of 69 Cases with Coronavirus Disease2019 inWuhan, China[J/OL]. Clin Infect Dis, 2020,[2020-03-26].https://www.ncbi.nlm.nih.gov/pubmed/32176772. [29] Deng L, Li C, Zeng Q, et al. Arbidol combined with LPV/r versus LPV/r alone against CoronaVirus Disease2019: A retrospective cohort study[J/OL]. J Infect,2020[2020-03-26]. https://www.ncbi. nlm.nih.gov/pubmed/term=Arbidol+combined+with+LPV%2Fr+versus+LPV%2Fr+alone+against+Corona+Virus+Disease+2019%3A+A+retrospective+cohort+study. [30] 傅晓霞, 林路平, 谭行华. 中西医结合治疗新型冠状病毒肺炎37例临床研究[J/OL].中药新药与临床药理,2020:1-9[2020-03-26].https://kns-cnki-net.vpn.ccmu.edu.cn/kcms/detail/44.1308.R.20200319.1644.002.html. [31] 肖琦, 蒋茵婕, 吴思思, 等. 中药疏风解毒胶囊联合阿比多尔治疗轻症新型冠状病毒肺炎的价值分析[J/OL].中国中医急症,2020:1-3[2020-03-26].https://kns-cnki-net.vpn.ccmu.edu.cn/kcms/detail/50.1102.R.20200309.1528.004.html. [32] 瞿香坤, 郝树立, 马景贺, 等. 疏风解毒胶囊联合阿比多尔治疗新型冠状病毒肺炎的回顾性研究[J].中草药,2020,51(5):1167-1170.
2020, Vol. 17 
